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This disruption of tight junctions results in an increase in the number of viral variants that successfully enter the lamina propria. There is good evidence that when someone is taking treatment and has an undetectable viral load, they cannot pass HIV on through sexual activity — including oral sex. Oral sex is practiced frequently both by heterosexual and homosexual couples 78and use of barrier protection during oral-genital contact, even in HIV transmission of hiv oral sex couples, is rare 668 Mackelprang RD, et al. Inhibition of HIV infectivity by transmission of hiv oral sex saliva. Mucosal infection of neonatal rhesus monkeys with cell-free SIV.